oregon scientific i600 software download

Associations between these MRFD and spatial memory were mediated by differences in posterior cingulate cortex volume (β = 0.0014 SE = 0.0006 P =. These regions overlapped neuroanatomically with those showing lower volumes in participants with AD, including the posterior cingulate cortex, the thalamus, the hippocampus, and the orbitofrontal cortex. Gray matter regions that showed relative atrophy associated with AD, aging, and greater numbers of MRFD.Īmong 8312 participants (mean age, 62.4 years 3959 men), aging and 4 major MRFD (ie, hypertension, diabetes, obesity, and frequent alcohol use) had independent negative associations with specific gray matter volumes. Primary analysis was conducted on April 1, 2018. The primary hypothesis was that common, overlapping regions would be found. Mediation models for risk factors, brain volume differences, and cognitive measures were tested. The potential clinical relevance of these associations was explored by comparing their neuroanatomical distributions with the regional brain atrophy found with AD. A voxelwise linear model was applied to test for regional gray matter volume differences associated with aging and MRFD (ie, hypertension, diabetes, obesity, and frequent alcohol use).

This cross-sectional study used data from UK Biobank participants who underwent T1-weighted structural brain imaging from August 5, 2014, to October 14, 2016. To characterize volume changes in brain regions associated with aging and modifiable risk factors for dementia (MRFD) and to test whether volume differences in these regions are associated with cognitive performance. Identifying brain regions associated with risk factors for dementia could guide mechanistic understanding of risk factors associated with Alzheimer disease (AD).

Oregon scientific i600 software download